James Gunn can refer to more than one person:

• James Gunn (film maker) (born 1970) American film maker, actor, and author.
• James Gunn (senator) (1753-1801) US Senator from Georgia
• James Gunn (congressman) (1843-1911) US Congressman from Idaho
• Sir James Gunn (painter) (1893-1965) UK Portrait painter
• James Gunn (educator) (1867-1927) American industrial engineer and educator
• James Gunn (author) (born 1923) American science fiction author
• James E. Gunn (born 1938) American Astronomer
• Sir James Gunn (explorer) of Scotland, explorer, member of Henry Sinclair's survey expedition in the 14th Century.